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Lexeo discloses new data for heart drug; Spark Therapeutics to lay off workers

Plus, news about Kashiv BioSciences: Lexeo Therapeutics reveals early data for heart disease drug: The New York biotech said LX2006 produced “clinically significant improvements” in heart function...

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RayThera secures $110M in Series A raise

RayThera has collected $110 million in a Series A raise to help it advance a preclinical pipeline of small molecule drugs for immunological diseases. The San Diego-based biotech will use the proceeds...

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Stock market melts down over Trump’s tariffs, and biotech's pain keeps growing

As President Donald Trump’s tariffs roil financial markets, biopharma is no exception. The XBI, an index fund viewed as the biotech’s market barometer, was down 3% in early trading Monday after closing...

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RFK Jr. won’t testify before key Senate committee this week on HHS overhaul

HHS Secretary Robert F. Kennedy Jr. won’t be appearing before a Senate panel on Thursday to testify on the massive restructuring of the health agency, despite an invitation from the committee’s...

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Drug tool and packaging makers to feel brunt of Trump tariffs, analysts say

Pharma tool and packaging production companies are readying themselves for direct impact from President Donald Trump’s tariffs, which could then have a knock-on effect on their biopharma and CDMO...

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‘This is self-inflicted’: Leerink’s David Risinger on the market shock and...

As the markets continued to fall Monday in response to the Trump administration’s tariff proposals, biotech has particularly been hit hard. The industry was already being hammered by firings at the FDA...

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Rare disease hub at CDER and CBER faces new reality with staff crunch

Amy Comstock Rick joined the FDA last November, and she not only survived the widespread staff cuts last week, she's one of only a handful of FDA officials to speak at a live conference since ...

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PureTech rejects cash exit proposal from Nordic Capital after deal talks

PureTech Health, a Boston biopharma company that has created drug developers like Karuna Therapeutics and Seaport Therapeutics, confirmed on Monday that it was in discussions with Nordic Capital...

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Federal judge in Minnesota dismisses drugmakers' 340B lawsuits

A federal judge in Minnesota knocked down challenges from two drugmakers against a state law that the companies argued overly expanded the scope of the government's 340B drug discount program. Judge...

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HHS says it may revisit policy for anti-obesity drugs

The government said it “may consider future policy options” for anti-obesity medications, after declining to finalize a Biden-era proposal that would have expanded coverage to millions of Medicare...

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Trump administration hikes Medicare Advantage payments by $25B

The Trump administration will hike payments to Medicare Advantage insurers by more than $25 billion next year, according to an annual rate announcement released Monday afternoon. CMS said payments to...

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US commission calls for $15B biotech investment to blunt China

A congressional commission is advocating for a $15 billion federal investment in America’s biotechnology sector, warning that the US could soon be eclipsed by China in a key frontier of innovation. In...

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Exclusive: Merida Biosciences gets $121M to treat autoimmune and allergy...

A scrappy team of drug developers has come together to create new medicines for patients with autoimmune diseases and allergies. They're going after the bustling subfield of Graves' disease and also...

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Cartesian reveals long-term mid-stage data for cell therapy in myasthenia gravis

Cartesian Therapeutics said its autologous CAR-T therapy has shown “sustained benefits” in people with a rare autoimmune disease according to the latest data cut from a Phase 2b trial. Four out of 12...

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Q&A: Lundbeck’s head of R&D on letting ‘biology speak’ in neuroscience

Johan Luthman has been running R&D at Lundbeck since 2019, and part of the neuroscience leader’s remit is helping steer development of a promising but still-experimental seizure medication that the...

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Rallybio ends development in rare disorder; ImmunityBio raises $75M

Plus, news about KalVista, Kaken Pharmaceutical, Lyell and Tango Therapeutics: Rallybio stops work on RLYB212: The company had been testing the drug to see if it could prevent fetal and neonatal...

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Novo Nordisk, HHS clash in court over IRA drug selection

Novo Nordisk focused on a unique argument in federal appeals court on Tuesday in a case that will consider the extent to which the judiciary can review which drugs HHS says are eligible for Medicare ...

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Kennedy's FDA cuts raise questions about 'trigger' for user fees

Last week's thousands of FDA job cuts will take a major chunk out of what the agency spends each year as part of its nearly $7 billion budget. But they could — theoretically — also have other ...

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What stock market chaos means for health tech

The markets have been volatile over the past few days, turned upside down by the tariffs announced by President Donald Trump. No industry has been spared. Our corner of health ...

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NIH appeals nationwide block on indirect cost cuts

The Trump administration on Tuesday said it will challenge a federal judge’s order that blocks its planned 15% rate limit on indirect cost reimbursements for NIH grant recipients nationwide. The...

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House panel mulls ways to boost struggling biosimilar market

The state of the US biosimilar market isn't as healthy as it should be despite significant advances in the past decade, health policy experts told a House panel on Tuesday. The US still struggles to ...

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Pharma CEOs warn EU of potential US exodus as trade war continues

Executives of major pharmaceutical companies warned the European Union that they’re likely to take the US’ side amid the threat of new tariffs. The European Federation of Pharmaceutical Industries and...

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Pharma is next in line as Trump says tariffs are coming 'very shortly'

President Donald Trump warned on Tuesday evening that “major” pharmaceutical tariffs will be coming “very shortly,” after previously exempting drugs from his earlier levy announcements. “We’re gonna do...

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Novo Nordisk looks to Brazil to boost GLP-1 manufacturing with $1B+ budget

Novo Nordisk is pouring 6.4 billion Brazilian reais ($1.05 billion) into a factory in Brazil, to ramp up production of its blockbuster GLP-1 drugs after it forecast relatively sluggish growth earlier...

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